The heatmap shows upregulated (red) and downregulated (green) peripheral blood genes, which show significant (p<0.005) differential expression in rejection-prone children with liver transplants (rejectors) compared with those who remain rejection-free (non-rejectors). Each horizontal row represents one of 40 differentially expressed genes. Each vertical row shows expression characteristics for all 40 genes for each of eight rejectors and eight non-rejectors (vertical rows). Note that the general trend toward upregulation of certain genes among rejectors is accompanied by downregulation of these genes among non-rejectors and vice versa. To illustrate, the genes DLL3, FLJ11183, Hs370168, LOC 119710, LOC 4-2152, RERG, FLJ90430 in the midportion of this heatmap are mostly downregulated in eight rejectors, but upregulated among eight non-rejectors. (Sindhi, 5RO1AI07895, 2006)
Transplant 2011 Special Edition of Pediatric INSIGHTS
This special issue of Pediatric Insights features 30 years of advances and innovation in pediatric transplantation at the Hillman Center for Pediatric Transplantation at Children's Hospital of Pittsburgh of UPMC. Learn what the future holds in pediatric transplantation by our experts.
Also in this issue:
- A conversation with Thomas E. Starzl, MD, PhD, about the role of pediatrics in the early days of transplantation.
- Children's specialists discuss ABCB4 disease and liver transplant for hepatoblastoma.
- A sampling of our most promising research.
- Our numbers speak for themselves: From diagnoses leading to transplant to our survival rates.
To discuss a case or to refer a patient to the Hillman Center for Pediatric Transplantation at Children's Hospital of Pittsburgh of UPMC, please call our Physician Referral Service at 412-692-PEDS (7337) or visit the Make a Referral section of Children's transplant website.